That will depend on what purpose you plan to put the card to. When shopping for credit cards, you will find that, by and large, the ones that charge an annual fee tend to be higher end cards, such as gold and platinum cards, and those that provide some sort of perk, such as frequent flier miles or points. There is not a substantial difference in interest rates where annual fees are concerned- this is much more a factor of the bank issuing the card, and their specific terms and services. The real decision will probably revolve around the rewards associated with the card, and whether or not it's worth paying the annual fee to receive them.
In general, it is best to go for the lowest possible interest rate. This is especially true whenever you expect to maintain a balance on the card for an extended period of time, such as a balance transfer from another credit card. Keep in mind that the larger the balance, the more will be saved through a low interest rate.
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